Human FGA Matched Antibody Pair set for ELISA useCapture Antibody: Mouse monoclonal anti-FGADetection Antibody: Rabbit purified polyclonal anti-FGA
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Antigen Detail | |
|---|---|
| Target | FGA |
| Description | Fibrinogen alpha chain is a protein that in humans is encoded by the FGA gene. Fibrinogen alpha chain is up-regulated and affects the pathogenesis of endometriosis. The role of proteasome activity for activating and inhibitory signalling in human platelets. A Novel Frameshift Mutation in the FGA Gene (c.196 delT) Leading to Congenital Afibrinogenemia. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Clone | IV01792 |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Rabbit |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human FGA Matched Antibody Pair set for ELISA use Capture Antibody: Mouse monoclonal anti-FGA Detection Antibody: Rabbit purified polyclonal anti-FGA |
| Specificity | Validated for detecting natural and recombinant human FGA |
| Research Area | Blood |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | FGA |
| Full Name | Fibrinogen Alpha Chain |
| Background | This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. |
| Alternative Names | Fib2 |
| Gene ID | 2243 |
| Uniprot ID | P02671 |
| GeneCards | FGA |
| HGNC | 3661 |
| Ensembl | ENSG00000171560 |
| OMIM | 134820 |
| Involvement in Disease | Diseases associated with FGA include Dysfibrinogenemia, Congenital and Afibrinogenemia, Congenital. |
| Function | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. |
| Related Pathways | Its related pathways are Activated TLR4 signalling and RET signaling. |
For Research Use Only.
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