Human FGF12 Matched Antibody Pair set for ELISA useCapture Antibody: Rabbit purified polyclonal anti-FGF12Detection Antibody: Mouse monoclonal anti-FGF12, IgG1 Kappa
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Antigen Detail | |
|---|---|
| Target | FGF12 |
| Description | Fibroblast growth factor 12 is a protein that in humans is encoded by the FGF12 gene. FGF12 regulates the BMP (bone morphogenic protein)-induced human pulmonary arterial smooth muscle cell phenotype change. FGF12 exerts antiproliferative and prodifferentiation effects in human pulmonary arterial smooth muscle cells via p38MAPK-dependent MEF2a (myocyte enhancer factor 2a) pathway activation. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Clone | RD10104 |
| Isotype | IgG1, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human FGF12 Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-FGF12 Detection Antibody: Mouse monoclonal anti-FGF12, IgG1 Kappa |
| Specificity | Validated for detecting natural and recombinant human FGF12 |
| Research Area | Angiogenesis |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | FGF12 |
| Full Name | Fibroblast Growth Factor 12 |
| Background | The protein encoded by this gene is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Alternative Names | FHF1; EIEE47 |
| Gene ID | 2257 |
| Uniprot ID | P61328 |
| GeneCards | FGF12 |
| HGNC | 3668 |
| Ensembl | ENSG00000114279 |
| OMIM | 601513 |
| Involvement in Disease | Diseases associated with FGF12 include Epileptic Encephalopathy, Early Infantile, 47 and Undetermined Early-Onset Epileptic Encephalopathy. |
| Function | Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation. |
| Related Pathways | Its related pathways are NF-KappaB Family Pathway and Activation of cAMP-Dependent PKA. |
For Research Use Only.
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