shRNA Adenovirus Serotype 5 (ΔE1/E3), pH1-(LIMS2-shRNA-Seq1)(CAT#: AdV-SI0650WQ)
This product is a LIMS2-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. LIMS2 gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The expression of LIMS2-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
Specifications | |
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Family | Adenoviridae |
Species | Adenovirus |
Serotype | HAdV-5 |
Backbone | AdV-5 (ΔE1/E3) |
Tropism | Both nondividing and dividing cells |
Insert | LIMS2-shRNA-Seq1 |
Related Target/Protein | LIMS2 |
Region | CDS |
TargetSeq | GAAGAACAAGTTTGTGGAGTT |
NCBI RefSeq | NM_017980 |
Alternative Names | LGMD2W; PINCH2; MDRCMTT; PINCH-2 |
Titer | >1*10^10 GC/mL |
Related Diseases | Muscular dystrophy, severe cardiomyopathy and triangular tongues |