Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsMembrane proteins are crucial targets for therapeutic intervention in numerous diseases. Notably, around 50% of currently available drugs focus on GPCRs. With their exceptional specificity and sensitivity, membrane protein antibodies hold immense potential and play unique roles in disease therapy. However, the research pertaining to the structure and activity of membrane proteins, including the study of membrane protein antibodies, has been slow due to the challenges of maintaining their activity and natural conformation in vitro. The development of membrane protein antibodies entails various difficulties, such as the preparation of membrane protein antigens, overcoming immune tolerance, and the diverse extracellular regions of target molecules. At Creative Biolabs, we offer a comprehensive membrane protein research platform tailored to meet your specific research needs.
The GPCR family plays a wide-ranging role in the physiological and pathological activities of organs and tissues, including the central nervous system, immune system, cardiovascular, and retina. Consequently, GPCRs have become popular targets for drug development, making them a hot research topic in therapeutic and diagnostic antibody development. Presently, antibody classes targeting GPCRs encompass a range of forms, including, naked antibodies, bispecific antibodies, antibody-drug conjugates, single domain antibodies, etc. The GPCR antibody development pipeline is rapidly evolving with increased clinical development capabilities. Antibody drugs targeting GPCRs offer three main advantages. Firstly, they possess unique drug-forming properties, enabling the blocking of GPCR-ligand binding and facilitating GPCR endocytosis, thereby reducing or terminating downstream signaling. Additionally, they can bind specific epitopes of the GPCR and stabilize the specific conformation of the GPCR upon activation, producing a biological activity with a preference. Secondly, antibody drugs exhibit excellent selectivity, particularly when binding to sites that are poorly conserved between receptors. Finally, the in vivo distribution of antibody drugs is noteworthy. While certain GPCRs are expressed in both the peripheral and central nervous systems, the ability of antibody drugs to penetrate the blood-brain barrier is limited. Consequently, designing drugs primarily for the peripheral part allows the development of therapeutic antibodies that mainly distribute in the peripheral region, minimizing toxic side effects on the central nervous system.
Abnormal ion channel function is associated with various diseases, such as type 2 diabetes, hypertension, epilepsy, cardiac arrhythmias, and anxiety disorders. Targeting ion channels presents a significant opportunity for drug treatment in these conditions. Although research on ion channel antibodies has faced technical obstacles and other challenges, recent progress has shown promising results. Several ion channel antibodies have exhibited favorable therapeutic effects in preclinical and clinical studies, validating their substantial therapeutic potential.
Transport proteins play vital roles in inflammation, immunity, biliary excretion, liver injury, chronic kidney disease, cancer, and many other areas. Additionally, they contribute to numerous physiological processes within the brain, including energy metabolism, the glutamate/gamma-aminobutyric acid-glutamine cycle, and blood-brain barrier function. Transporters exhibit significant diversity, with unique molecular structures that make them specific substrates or inhibitors for many drugs, resulting in diverse therapeutic effects. Due to their high specificity and sensitivity, anti-transporter antibodies represent an essential avenue for drug development targeting transporters.
Introduction to Membrane Protein Types
Introduction to Membrane Protein Formats
Introduction to Membrane Protein Antibody Discovery Strategies
At Creative Biolabs, we aim to share key points and experiences regarding anti-membrane protein antibodies to facilitate the smooth progression of your project.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
