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Magic™ Membrane Protein Biotinylated Human CLDN18 (Claudin 18) Expressed in HEK293, Full Length (CAT#: MPX0561K)

Datasheet
This product is a 29 kDa Biotinylated Human CLDN18 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CLDN18
  • Protein Length
  • Full length
  • Protein Class
  • Receptor
  • Molecular Weight
  • 29 kDa
  • TMD
  • 4
  • Sequence
  • MSTTTCQVVAFLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLW
    RSCVRQSSGFTECRPYFTILGLPAMLQAVRALMIVGIVLGAIGLLVSIFA
    LKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMS
    TANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLA
    PEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDE
    VQSYPSKHDYV

Product Description

  • Activity
  • Yes
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Endotoxin
  • <1.0 EU per 1 μg of the protein by the LAL method.
  • Purity
  • > 95% as determined by SEC-HPLC
  • Buffer
  • Supplied as 0.22um filtered solution in PBS, pH 7.4

Target

  • Target Protein
  • CLDN18
  • Full Name
  • Claudin 18
  • Introduction
  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Alternative Names
  • CLDN18; SFTA5; SFTPJ; claudin-18; surfactant associated 5; surfactant associated protein J; surfactant, pulmonary associated protein J; Claudin 18

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