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Antibody-Drug Conjugation Service

Creative Biolabs is the industry leading expert in antibody engineering and can utilise our experience to provide comprehensive services for the conjugation and characterisation of antibody-drug conjugates. With years of experience in a variety of cell based bioassays and binding assays, we provide comprehensive expertise to support the development of antibody-drug conjugate products for all phases of drug development from discovery to GMP manufacturing.

Antibody-Drug Conjugation Service
Antibody-drug conjugates (ADCs) are a new class of highly potent biopharmaceutical drugs designed as a targeted therapy for the treatment of people with cancer. ADCs are complex molecules composed of an antibody linked, via a stable, chemical linker to a biological active cytotoxic (anticancer) payload or drug. Therapeutic monoclonal antibodies may be conjugated with a wide array of different molecules. Using the highly specific and selective targeting mechanism of antibody, the ADC can discriminate with great sensitivity between normal and cancerous tissues, allowing a significant reduction in the therapeutic dose of the drug and reducing the toxic side effects to patients.

Creative Biolabs provides a wide range of services to support the characterization of various forms of antibodies that can be applied to antibody drug conjugates, which including almost all the monoclonal and engineered antibodies on our website. Our scientists are pleased to offer site-specific antibody-drug conjugation services based on traditional strategy as well as unique conjugation strategy developed at Creative Biolabs. Small drugs or toxins can be conjugated to an antibody at a specific site away from the antigen binding site.

We offer a series of Antibody-Drug Conjugation Services

• Conjugation of drug or toxin to antibody
• Protein-drug bio-conjugates
• Characterization of antibody-drug conjugates by size exclusion chromatography and UV/Vis spectrometry
• Binding and immunoassays

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