This product is a GA-10 (Clone 4) B cell engineering tool based on the Magnetic nanoparticles (LRP-1 targetingpeptide/Lipoproteinreceptor-related protein-1) delivery system and CRISPR-based (hROSA26-tracr RNA-Cas9-RS-1 ) genome editor.
| Host Cell | GA-10 (Clone 4) |
| Target | ACTN1 |
| Insert Clone | D6F6 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Mouse genome E-8 |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | LRP-1 targeting peptide/Lipoprotein receptor-related protein-1 |
| Active Agents | Thymoquinone |
| Particle Size | 10-50 |
| Charge (mv) | 13 to 65 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Renal cancer; Lung cancer; Head and Neck cancer; Urothelial cancer |
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