Plasma cells are bone marrow-located antibody production cells that are derived from mature native B cells and memory B cells. The establishment of plasma cells is a complex B-cell lineage transition process that starts from antigens binding to the receptor of naive B cells. The deep insights into the construction process showed that this process is controlled by a combined cell intrinsic gene regulation network and extracellular signals from the surrounding microenvironment. Plasma cells have become a novel medicine for oncology due to the capability to secrete fusion protein and perform a long-lasting treatment.
Creative Biolabs is a world-famous service provider for immunotherapy development and is specialized in plasma cell establishment from B cells. With the increasing knowledge on the plasma cell differentiation from B cells, scientists from Creative Biolabs offers plasma cell generation from B cells depending on the crucial germinal center (GC) reaction and drive transcript factors involved in lineage transition.
We present our robust B cell differentiation platform by providing comprehensive services to guide B cell transition into therapeutic plasma cells by regulating gene transcriptional networks and modulating cell-extrinsic factors and signals. In addition, we are devoted to characterizing metabolomic changes of the B cell to plasma cell transition based on cutting-edge techniques using NMR and UPLC-TOF-MS. Our services include but are not limited to below.
The B cell-intrinsic differentiation process is constantly affected by activated helper T cells within the follicle foci.
Based on years of research on B cell development and differentiation, Creative Biolabs offers plasma cell development service using helper T cell-derived cytokines and ligand-receptor interactions, producing protein-secreting, bone marrow-destined plasma cells.
The transit to the plasma cell from the B cell is regulated by the fundamental transcription factors associated with gene expression.
Creative Biolabs utilizes the property of transcriptional circuitry of B cell differentiation and manipulates gene expression at the transcriptional level, controlling activated B cell transition to functional plasma cells.
When B cells transition into medicine plasma cells under cell-intrinsic regulatory pathways, the cellular metabolism has changed.
Creative Biolabs provides multidimensional advanced nuclear magnetic resonance (NMR) spectroscopy to study the exo-metabolome of differentiating B cells, including 1D-1H NMR, 2D-1H1H-TOCSY, and 2D-1H13C-HSQC spectra.
The metabolic footprint is used to determine metabolites contributing to the generation of enhanced plasma cells.
Creative Biolabs offers a comparative metabolomics service using the ultra-performance liquid chromatographic (UPLC) system linked to mass time-of-flight mass spectrometry (TOF-MS).
| B Cell Genome Editing Service | Engineering B cell at various gene loci using advanced techniques, such as: |
| Engineer B Cell for Immunotherapy | Endowing B cell with enhanced functions, including: |
| B Cells Assessment Service | Evaluate engineered B cell characteristics and functions using multiple in vivo and in vitro assays. |
Our abundant experience in antibody and cell and gene therapy discovery makes us an ideal partner for engineered B cell therapy research. If the above services are not your interest, please contact us and talk with our expert for a specific solution designed for your particular demands.