The ultimate mission of engineering B cells immunotherapy is to provide robust and durable protection against pathogen infections. Such protection is mainly mediated by two "walls", which are long-lived plasma cells and memory B cells (shown in Fig.1). After a series of gene editing, expansion, transplantation, and differentiation, assessment of whether the edited B cells could form a lifelong protection immunity is an imperative and inevitable need. Creative Biolabs offers the service of protection effect analysis of edited B cells in vitro and in vivo for our customers worldwide.
We offer scientific and comprehensive services for B cell protection effect analysis, including flow cytometry assay (FC), viral titer assay, and comprehensive data analysis to ensure high-quality B cell engineering results. To get more information about the functional assessment of engineered B cells in vivo and in vitro, please inquire about our Engineered B Cells Assessment Service.
Fig.1 Our protection effect analysis service. (Creative Biolabs)
Creative Biolabs is committed to efficiency, confidentiality, and rapid, accurate protection effect analysis service with proven experience and expertise.
Fig.2 Our features and benefits. (Creative Biolabs)
Paper Title: B cells engineered to express pathogen-specific antibodies protect against infection
Technology: CRISPR/Cas9; Protection Effect Analysis
Subjects: RAMOS B cells and Primary human B cells
Journal: Science Immunology
Published: 2019
Background: Many crucial infections such as respiratory syncytial virus (RSV), human immunodeficiency virus (HIV), influenza and Epstein Barr virus (EBV) are not yet available to get effective vaccines inducing lifelong protection despite decades of research.
Results: B cells engineered to express an antibody resulted in durable, potent, and stable protection against RSV infection in immunodeficient RAG1−/− mice.
Q: When protection effect analysis is needed in B cell engineering immunotherapy?
A: It is needed when you quantify the protective ability and protective range of the engineered B cells. It is needed when you verify whether the engineered B cells could provide long-term protection in animals without side effects.
Creative Biolabs has established a professional and experienced team, who are dedicated to providing protection effect analysis to help our clients in B cell engineering immunotherapy. Please contact us for more information.