B Cell Engineering Cassette Products

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    With our end-to-end B cell engineering platform, Creative Biolabs harnesses a combination of B cell engineering technologies and genome editing to help us design, build, and test the next generation of B cell engineering cassette tools at an extraordinary scale.

    The unique potential of B cells in gene therapy lies in their ability to secrete abundant proteins such as antibodies and persist as plasma cells. Here, Creative Biolabs provides a range of optimized cassettes for modifying human B cells. Normally, our product production process involves B cell enrichment, activation, amplification, and electroporation of CRISPR/Cas9 reagents. In our labs, B cell delivery is performed approximately 3-4 days after stimulation, with peak expression observed on days 7-9 post-stimulation. Through our B cell engineering cassette, we enable rapid and precise targeting of genes related to B cell function and achieve protein knockouts effectively. Currently, we can expand the total number of cultured B cells by over tenfold while achieving a knockout rate exceeding 60% and site-specific integration frequency as high as 20%.

    B Cells Are Efficiently Edited by CRISPR/Cas9.1 Fig. 1 B Cells Are Efficiently Edited by CRISPR/Cas9.1

    Creative Biolabs offers a wide variety of B-cell engineering cassette products, all of which have been rigorously verified for quality and performance, such as biological activity, batch-to-batch consistency, and purity. Our platform enables produce engineered b cells with increased efficacy, safety, and accessibility. These novel products can deliver directed, responsive therapy activities in a cost-effective manner. Please the see main B cell engineering cassette product details below.

    Reference
    1. Johnson, M. J.; et al. Engineering of primary human B cells with CRISPR/Cas9 targeted nuclease. Scientific Reports, 2018, 8(1): 12144.

    ! All products and services are for Research Use Only. Not For Clinical Use.
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