B Cell Engineering Specific VP Products

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    Relying on a strong gene editing and B cell therapy research and development platform, Creative Biolabs has independently developed a series of virus packaging systems, including but not limited to, lentivirus (LV), adenovirus (ADV), and adeno-associated virus (AAV), which can provide customers with high-quality viral vectors specific for B-cell engineering.

    Currently, we have developed a high-throughput virus packaging platform that utilizes automated instrumentation and a rich gene editing library, like CRISPR/Cas9, to achieve more efficient B cell modification solutions with delivery as fast as 3-4 weeks and a virus titer of > 106 IFU/mL. Moreover, we are committed to quality control testing of all samples, including p24 titer testing and mycoplasma testing.

    In Vitro B Cell Stimulation And Transduction. (Chu, et al., 2017) Fig.1 In Vitro B Cell Stimulation And Transduction. 1

    Service Procedures

    In Creative Biolabs, our previous work has focused on editing primary human B cells, and then using viral vectors to express specific monoclonal antibodies (Mabs) to mature them into B cells in vitro. Our CRISPR/Cas9 technology system can greatly improve the editing efficiency of B cells, which can reach more than 60%. In addition, we continue to explore virus packaging types and combine them with CRISPR/Cas9 systems to develop more efficient DNA template donors.

    ✩ Customer provided

    If the customer possesses the target gene, we can provide the corresponding plasmid or bacterial solution upon request.

    ✩ Provide information

    Please provide us with information regarding the target gene, including its name, species, sequence, and gene ID. Additionally, inform us about any specific requirements for promoters and marker genes, gene editing, and b cell engineering.

    ✩ Product delivery

    Normally, for lentivirus delivery, we will send a total of 1×108 TU with a titer greater than 1×108 TU/mL. Adenovirus delivery includes a total of 1×1010 PFU with a titer greater than 1×1010 PFU/mL. An equal amount of negative control will be provided as well. For other types of virus delivery, you can further contact us for consultation.

    ✩ Data delivery

    Customers will receive a virus packaging report containing experimental data such as sequencing reports, virus identification data, titer determination reports, and detailed experimental data on vector construction.

    Specifications Delivery Standard Application ETA Price
    Standard Size 1×108 TU B Cell Engineering 2-3 weeks Please inquiry!
    Large Size 1×108 TU B Cell Engineering 3-4 weeks
    Purified Virus 1×108 TU In Vivo Injection 3-4 weeks

    Why Choose Us?

    • Good safety, the use of security.
    • Efficient integration of target genes into the genome of the engineered B cell.
    • Stable and efficient expression.
    • Applicable to a variety of type B cells and has a high infection efficiency.
    • Large gene capacity.
    • High virus titer is high and a Large total amount.

    Creative Biolabs provides gene editing solutions for B cells, offers customized services based on the target gene and editing region specified by the customer, and gives technical support for the field of B cell therapy with delivery systems that support many types of viruses. If you are interested in our B-cell engineering VP products or services, please free to contact us.

    Reference
    1. Chu, V. T.; et al. CRISPR/Cas9-mediated in vitro mutagenesis in GC-like B cells. Germinal Centers: Methods and Protocols, 2017, 135-145.

    ! All products and services are for Research Use Only. Not For Clinical Use.
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