Gene or cell therapy provides the potential for the natural, continuous production and delivery of therapeutic proteins using human cells. B cells are key players of adaptive immunity and can be applied as cellular vehicles for long-term, systemic, and antigen-regulated delivery of therapeutic proteins. Some recent genetic engineering work has focused on taking advantage of the potent protein secretion capabilities of B cells to produce non-antibody therapeutic proteins for the treatment of a wide range of diseases. B cells have been widely modified to express diverse therapeutic proteins such as
Creative Biolabs has relentlessly focused on state-of-the-art cell therapy technologies in the world. Leveraging state-of-the-art gene editing technologies, rich expertise in B cell biology, and years of experience in cell therapy, our team of experts has developed one-stop B cell engineering services that support the complete experimental workflow; from cell isolation and engineering to functional analysis. To help keep researchers moving forward, our scientists provide experience and expertise in genetically engineering B cells for delivering continual, high doses of a therapeutic protein. Modified B cells can live for a long time and have the capacity to secrete extremely high levels of multiple therapeutic proteins, including
| Services | Deliverables |
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B cell preparation Synthesis and delivery of gene of interest Positive cells screening Gene expression evaluation Cell expansion and differentiation Engineered B cells assessment |
Engineered B cells Final Report |
Fig.1 Workflow of B cell engineering. (Creative Biolabs)
| Project Consultation | Project Execution | Project Delivery |
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Evaluate project feasibility Detailed work plan |
B Cell Engineering Method optimization Functional assessment |
Validated B cells Final report |
Please feel free to contact us for experimental design and protocol development.