Creative Biolabs has built a perfect engineered B cell medicines platform to provide transformative therapies for your different disease researches, opening a new and paradigm-shifting class of cell therapy.
Except for antibody production, the B cells are involved in a wide array of functions of the immune response. Such as inflammation, antigen presentation, memory formation, and cytokine secretion.
Immune effector function of B cell:
Creative Biolabs provides One-Stop Solution for B Cell Engineering, which includes a comprehensive range of site and technology services to support scientific research in immunotherapy. You can find any needed service for your project.
Fig.1 One-stop solution for B cell engineering. (Creative Biolabs)
By precision genome engineering technology to insert a gene into an exact chromosomal location. Creative Biolabs creates many B cell candidates for multiple diseases by swapping in different genes of interest. Then, the engineered B cells are expanded and differentiated into plasma cells that secrete the desired therapeutic antibody or protein by changing culture conditions.
B cells can generate proteins and play key roles in humoral immunity. B cells can differentiate into different plasma cells, which secrete antibodies. B cells also secrete cytokines that can affect T-cell function, dendritic cell (DC) function, and lymphoid tissue reorganization.
Fig.2 Types of B cell engineering for immunotherapy. (Creative Biolabs)
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| B Cell Engineering Service for Therapeutic Antibody Delivery | B Cell Engineering Service for Therapeutic Protein Delivery | Engineering B Cells with Enhanced IMMUNO-Regulatory Properties |
| Creative Biolabs provides proprietary B cell engineering services for therapeutic antibody delivery which can act as membrane-bound surface receptors known as B cell receptors or are secreted as proteins that contribute to immunity in different ways. | Creative Biolabs provides B cell engineering services to manufacture proteins to help your immune research. We could engineer B cells to produce any therapeutic protein you needed. We have developed a unique method for gene delivery to primary human B cells, which is an important technology to build a cell therapy for protein delivery. | Creative Biolabs provides B cell engineering services to regulate the secretion of costimulatory immune cell ligands and immuno-regulatory molecules. We could engineer B cells and change the immuno-regulatory properties to meet your immunology research needs. |
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Features & Benefits
Professional consultation provides guidance before, during and after the B cell engineering project, please contact us for your tailored solution.
Q1. What are the applications of engineered B cells?
| Application | Description |
|---|---|
| Antibody production | Protection from pathogens |
| Antigen presentation | T cell activation; T cell memory |
| Co-stimulation | T cell activation; T cell memory |
| Tertiary lymphoid organ formation | In-situ immune response |
| Cytokine-mediated stimulation | T cell cytokines; T cell memory |
| Cytokine-mediated inhibition | Reduced T cell activation Increased Tregs; Decreased inflammatory cytokines |
