B cells are valuable tools for developing therapeutic drugs, with several advantages: natural secretory cells for antibodies and cytokines, the ability to differentiate into long-lived memory and plasma cells, and the ability to function as APCs. Therefore, B cell-based therapies have opened new possibilities for potentially curing disease by the delivery of biologics. Creative Biolabs has developed a tightly integrated platform to help you develop and deliver engineered B cell products. Our genome engineering technologies and B cell expertise give us a unique advantage over other companies. A team of scientists is dedicated to helping our clients accelerate the pace of cell therapy development.
Engineered B cells can be flexibly tailored to your requirements by several technologies.
CRISPR/Cas9-based Genome Editing
We provide an efficient CRISPR/Cas9 system to insert gene of interest into the safe harbor locus, as a step toward future B cell engineering.
We offer complete custom TALEN solutions and services for genomic modification in B cells.
Homology-directed Repair (HDR)
An efficient method for introducing stable protein expression into B cells is genome editing via homology-directed repair (HDR).
Lentiviral vectors can mediate high-level gene transfer in B cells by the non-site specific integration.
Adeno-associated Virus (AAV) Vector
B cell engineering can be performed by adeno-associated virus (AAV) vector-mediated gene delivery.
This is a list of our most frequently asked questions:
Yes, you can provide your own cell lines or available B cells can be provided by Creative Biolabs for an additional fee. We also offer services for the purification, culture, and activation of primary B-lymphocytes.
These technologies vary from efficiency, price, genomic location of transgene integration, and specificity. You can choose a service at your own discretion or contact us to discuss.
The price varies depending on the project requirements. To generate a full quote, we recommend contacting our team to go through project requirements in more detail.
It depends on the complexity of the project. Feel free to contact us to discuss your project.
We will provide engineered B cells and final report.
Please contact us to learn more about our B Cell Engineering Service