Metabolomics is a powerful technique for the systematic study of plasma cell differentiation biology. With rich knowledge of cutting-edge metabolite profiling technologies and expertise, Creative Biolabs provides high-quality and complete metabolomics of B cell to plasma cell differentiation.
Engineered B cells should be induced to differentiate into plasma cells and become long-lived, protein-secreting cells to perform potential oncology therapeutic functions. When B cells bind antigens in vivo, this complex B cell differentiation process involves proliferation, isotype switching, affinity maturation, and terminal differentiation. As a profound metamorphosis of the genome to proteomic scale occur to generate antibody-secreting plasma cell, metabolomics analysis can be applied to elucidate the plasma cell differentiation process by comparing primary B cells and differentiating B cells using metabolomics technologies to explore and identify compounds of biochemical reactions, uncovering the metabolic pathways and processes in specific cells.
Using the advanced metabolomics technique, Creative Biolabs globally explore the metabolites in differentiating B cell and primary B cell controls, providing a better understanding of the differentiation process. We use the exometabolome as a metabolomics strategy focusing on the extracellular medium to characterize the component consumed or released to the culture medium during the differentiation process from protein-secreting B cell to long-lived plasma cell.
Our services include B cell to plasma cell differentiation solutions, plasma cell metabolite profiling by NMR, and UPLC-TOF-MS. Our metabolites analysis by NMR and MS will provide clients with a complete and systematic view of the differentiation process to support your engineered B cell-based therapeutic cell product discovery research.
Nuclear magnetic resonance spectroscopy (NMR) is an advanced and sensitive technique that can be used for metabolomics studies.
UPLC-MS technique is a sensitive and high-performance detection method for the identification and quantity of metabolites in biofluids and tissue samples.
Creative Biolabs is a lead service provider in the metabolomics study of the B cell to plasma cell differentiation. If the service you are looking for is not shown in the above modules, please contact us and let us know your interest. We will try our best to offer a unique solution to your project.