This product is a CA46 B cell engineering tool based on the Magnetic nanoparticles (LRP-1 targetingpeptide/Lipoproteinreceptor-related protein-1) delivery system and CRISPR-based (CCR5-huIgH296-SpCas9-L755507 ) genome editor.
| Host Cell | CA46 |
| Target | AFP |
| Insert Clone | 2B33 |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | huIgH296 |
| Nuclease | SpCas9 |
| Enhancer | L755507 |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | LRP-1 targeting peptide/Lipoprotein receptor-related protein-1 |
| Active Agents | Thymoquinone |
| Particle Size | <500 |
| Charge (mv) | −2 to -30 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Colon cancer; Lung cancer; Ovarian cancer |
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