This product is a Raji B cell engineering tool based on the Nanoparticles (MUC1 aptamer/MUC1) delivery system and CRISPR-based (CCR5-sgRNA-SpCas9-Brefeldin A ) genome editor.
| Host Cell | Raji |
| Target | AFP |
| Insert Clone | 7C6 |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | sgRNA |
| Nuclease | SpCas9 |
| Enhancer | Brefeldin A |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Mouse genomeD-4(2) |
| Vehicles | Nanoparticles |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | Celastrol |
| Particle Size | 20-3500 |
| Charge (mv) | 0 to -16 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Breast cancer; Colon cancer; Lung cancer; Ovarian cancer |
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