This product is a Raji B cell engineering tool based on the Sphingosomes (Hyaluronic acid/ RHAMM, CD44) delivery system and CRISPR-based (SHS-317-SpCas9-NLS-Cas9-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | Raji |
| Target | BCMA |
| Insert Clone | BG-24B |
| Safe Harbor Sites (SHS) | SHS-317 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Sphingosomes |
| Ligand/Receptor | Hyaluronic acid/ RHAMM, CD44 |
| Active Agents | Bortezomib |
| Particle Size | <2300 |
| Charge (mv) | < 0.5 |
| Total Atom Count | -57000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | Baculovirus-AAV |
| Vector Name | BCpCDH4 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Colon cancer |
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