This product is a BC-3 B cell engineering tool based on the Solid lipid nanoparticles (MUC1 aptamer/MUC1) delivery system and CRISPR-based (hROSA26-tracr RNA-Cas9-RS-1 ) genome editor.
| Host Cell | BC-3 |
| Target | BCMA |
| Insert Clone | P-FFMF-353 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | Thymoquinone |
| Particle Size | 20-3500 |
| Charge (mv) | −25 to -125 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Colon cancer |
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