This product is a SU-DHL-4 B cell engineering tool based on the Gold nanoparticles (N-acetyl-D-glucosamine, sialic acid/Wheat germ agglutinin) delivery system and CRISPR-based (SHS-229-huIgH296-Cpf1-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | SU-DHL-4 |
| Target | BKV VP1 |
| Insert Clone | 2IQ871L-T8-5 |
| Safe Harbor Sites (SHS) | SHS-229 |
| gRNA | huIgH296 |
| Nuclease | Cpf1 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH-dependent |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | N-acetyl-D-glucosamine, sialic acid/Wheat germ agglutinin |
| Active Agents | Thymoquinone |
| Particle Size | <500 |
| Charge (mv) | −2 to -31 |
| Total Atom Count | -73000000 |
| Surface Atoms (%) | -0.6 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Lung cancer; Brain cancer; Colon cancer; Ovarian cancer |
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