This product is a BC-2 B cell engineering tool based on the Nanoparticles (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (CCR5-huIgH296-Cas12-RS-1) genome editor.
| Host Cell | BC-2 |
| Target | CCL2 |
| Insert Clone | BG-64E |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | huIgH296 |
| Nuclease | Cas12 |
| Enhancer | RS-1 |
| Targeting Strategy | pH-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Nanoparticles |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 10-500 |
| Charge (mv) | 6 to 92 |
| Total Atom Count | -22,000,000 |
| Surface Atoms (%) | -3 |
| Specific Surface Area (m2/g) | -9 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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