This product is a BC-3 B cell engineering tool based on the Nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (AAVS1-sgRNA-SpCas9-RS-1) genome editor.
| Host Cell | BC-3 |
| Target | CCL2 |
| Insert Clone | BG-67E |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | sgRNA |
| Nuclease | SpCas9 |
| Enhancer | RS-1 |
| Targeting Strategy | pH-dependent |
| Insertion sites | Human genome |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | <2300 |
| Charge (mv) | -29 to -80 |
| Total Atom Count | -22,000,000 |
| Surface Atoms (%) | -3 |
| Specific Surface Area (m2/g) | -9 |
| Vector Type | RABV |
| Vector Name | BCpCDH8 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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