This product is a Ramos (RA 1) B cell engineering tool based on the Dendrimers (Transferrin/Transferrin receptor) delivery system and CRISPR-based (AAVS1-SpCas9-NLS-Cas9-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | CCL2 |
| Insert Clone | BG-68E |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Mouse genome E-1 |
| Vehicles | Dendrimers |
| Ligand/Receptor | Transferrin/Transferrin receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | <100 |
| Charge (mv) | 10 to 31 |
| Total Atom Count | -22,000,000 |
| Surface Atoms (%) | -3 |
| Specific Surface Area (m2/g) | -9 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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