This product is a Ramos (RA 1) B cell engineering tool based on the Sphingosomes (EpCAM aptamer/Epithelial celladhesion molecule) delivery system and CRISPR-based (AAVS1-SpCas9-NLS-Cas9-(Z)-4-Hydroxytamoxifen ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | CCNB1 |
| Insert Clone | 5G6 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Large DNA sequences |
| Vehicles | Sphingosomes |
| Ligand/Receptor | EpCAM aptamer/Epithelial cell adhesion molecule |
| Active Agents | Celastrol |
| Particle Size | <2500 |
| Charge (mv) | 10 to 55 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | RABV |
| Vector Name | BCpCDH8 |
| Targeting Diseases | Breast cancer; Lung cancer; Acute-myeloid-leukemia |
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