This product is a Ramos (RA 1) B cell engineering tool based on the Dendrimers (Mannose/Mannose receptor) delivery system and CRISPR-based (huROSA-26-tracr RNA-Cas9-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | CCP |
| Insert Clone | BG-77E |
| Safe Harbor Sites (SHS) | huROSA-26 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Dendrimers |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | <1000 |
| Charge (mv) | 0 to -31 |
| Total Atom Count | -22,000,000 |
| Surface Atoms (%) | -3 |
| Specific Surface Area (m2/g) | -9 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Prostate cancer; Lung cancer; Ovarian cancer |
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