This product is a Ramos (RA 1) B cell engineering tool based on the Gold nanoparticles (EpCAM aptamer/Epithelial cell adhesion molecule) delivery system and CRISPR-based (huROSA-26-sgRNA-Cpf1-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | CCR2 |
| Insert Clone | BG-83E |
| Safe Harbor Sites (SHS) | huROSA-26 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | EpCAM aptamer/Epithelial cell adhesion molecule |
| Active Agents | [Ru(bpy)2(tip)]2+, RBT |
| Particle Size | <100 |
| Charge (mv) | 13 to 67 |
| Total Atom Count | -22,000,000 |
| Surface Atoms (%) | -3 |
| Specific Surface Area (m2/g) | -9 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Colorectal cancer; Lung cancer |
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