This product is a Raji-Luc B cell engineering tool based on the Nanoparticles (N-acetyl-D-glucosamine, sialic acid/Wheat germ agglutinin) delivery system and CRISPR-based (huROSA-26-sgRNA-Cpf1-SCR7 pyrazine) genome editor.
| Host Cell | Raji-Luc |
| Target | CCR4 |
| Insert Clone | BG-88E |
| Safe Harbor Sites (SHS) | huROSA-26 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Large DNA sequences |
| Vehicles | Nanoparticles |
| Ligand/Receptor | N-acetyl-D-glucosamine, sialic acid/Wheat germ agglutinin |
| Active Agents | DOX |
| Particle Size | 10-1000 |
| Charge (mv) | 15-60 |
| Total Atom Count | -22,000,000 |
| Surface Atoms (%) | -3 |
| Specific Surface Area (m2/g) | -9 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Colon cancer; Lung cancer; Ovarian cancer |
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