This product is a NAMALWA B cell engineering tool based on the Gold nanoparticles (Transferrin/Transferrin receptor) delivery system and CRISPR-based (AAVS1-SpCas9-NLS-Cas9-RS-1) genome editor.
| Host Cell | NAMALWA |
| Target | CCR4 |
| Insert Clone | BG-89E |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | RS-1 |
| Targeting Strategy | pH responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Transferrin/Transferrin receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 10-1000 |
| Charge (mv) | < 0.5 |
| Total Atom Count | -22,000,000 |
| Surface Atoms (%) | -3 |
| Specific Surface Area (m2/g) | -9 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Breast cancer; Colon cancer; Lung cancer; Ovarian cancer |
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