This product is a Ramos (RA 1) B cell engineering tool based on the Solid lipid nanoparticles (Anti-EGFR mAb/Epidermal GrowthFactor Receptor) delivery system and CRISPR-based (AAVS1-sgRNA-Cpf1-RS-1 ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | CCR8 |
| Insert Clone | R6R171 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Human genome |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | <2500 |
| Charge (mv) | −2 to -30 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | VSV |
| Vector Name | BCpCDH7 |
| Targeting Diseases | Breast cancer; Lung cancer |
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