This product is a Ramos (RA 1) B cell engineering tool based on the Niosomes (Anti-EGFR mAb/Epidermal GrowthFactor Receptor) delivery system and CRISPR-based (AAVS1-sgRNA-Cpf1-RS-1 ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | CD11b |
| Insert Clone | 2A1 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH-dependent |
| Insertion sites | Human genome |
| Vehicles | Niosomes |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | Thymoquinone |
| Particle Size | <2500 |
| Charge (mv) | ≤50 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | VSV |
| Vector Name | BCpCDH7 |
| Targeting Diseases | Pancreatic cancer; Ovarian cancer; Breast cancer; Colon cancer; Melanoma |
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