This product is a CA46 B cell engineering tool based on the Magnetic nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (CCR5-crRNA:tracrRNA duplex-Cas9-RS-1 ) genome editor.
| Host Cell | CA46 |
| Target | CD11b |
| Insert Clone | LM3/3 |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | <2500 |
| Charge (mv) | <-1 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Pancreatic cancer; Ovarian cancer; Breast cancer; Colon cancer; Melanoma |
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