This product is a RPMI 8226 B cell engineering tool based on the Dendrimers (Hyaluronic acid/ RHAMM, CD44) delivery system and CRISPR-based (AAVS1-tracr RNA-Cas9-RS-1 ) genome editor.
| Host Cell | RPMI 8226 |
| Target | CD171 |
| Insert Clone | BCR-3 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Dendrimers |
| Ligand/Receptor | Hyaluronic acid/ RHAMM, CD44 |
| Active Agents | DOX |
| Particle Size | <500 |
| Charge (mv) | −18 to -84 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Lung cancer; Ovarian cancer |
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