This product is a DG-75 [D.G.-75] B cell engineering tool based on the Solid lipid nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (hROSA26-huIgH296-Cas12-RS-1 ) genome editor.
| Host Cell | DG-75 [D.G.-75] |
| Target | CD19 |
| Insert Clone | BCR-32 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | huIgH296 |
| Nuclease | Cas12 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | ESC8 |
| Particle Size | <500 |
| Charge (mv) | <80 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | MSCV |
| Vector Name | BCpCDH6 |
| Targeting Diseases | Breast cancer; Lung cancer; Ovarian cancer |
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