This product is a Raji-Luc2 B cell engineering tool based on the Nanoparticles (MUC1 aptamer/MUC1) delivery system and CRISPR-based (SHS-323-huIgH296-SpCas9-SCR7 pyrazine ) genome editor.
| Host Cell | Raji-Luc2 |
| Target | CD19 |
| Insert Clone | BCR-37 |
| Safe Harbor Sites (SHS) | SHS-323 |
| gRNA | huIgH296 |
| Nuclease | SpCas9 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | pH-dependent |
| Insertion sites | Mouse genome E-4 |
| Vehicles | Nanoparticles |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 10-1000 |
| Charge (mv) | −25 to -125 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Lung cancer; Ovarian cancer |
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