This product is a RPMI 8226 B cell engineering tool based on the Nanoparticles (Anti-EGFR mAb/Epidermal GrowthFactor Receptor) delivery system and CRISPR-based (AAVS1-sgRNA-Cas9-RS-1 ) genome editor.
| Host Cell | RPMI 8226 |
| Target | CD2 |
| Insert Clone | 10B970 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | sgRNA |
| Nuclease | Cas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Human genome |
| Vehicles | Nanoparticles |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | Thymoquinone |
| Particle Size | <2500 |
| Charge (mv) | 0 to -30 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | VSV |
| Vector Name | BCpCDH7 |
| Targeting Diseases | Breast cancer; Prostate cancer; Lung cancer; Ovarian cancer |
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