This product is a Ramos (RA 1) B cell engineering tool based on the Gold nanoparticles (EpCAM aptamer/Epithelial celladhesion molecule) delivery system and CRISPR-based (CCR5-huIgH296-Cpf1-Brefeldin A ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | CD2 |
| Insert Clone | 10B972 |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | huIgH296 |
| Nuclease | Cpf1 |
| Enhancer | Brefeldin A |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Mouse genomeD-4(2) |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | EpCAM aptamer/Epithelial cell adhesion molecule |
| Active Agents | Celastrol |
| Particle Size | <2500 |
| Charge (mv) | −2 to -30 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | MSCV |
| Vector Name | BCpCDH6 |
| Targeting Diseases | Breast cancer; Prostate cancer; Lung cancer; Ovarian cancer |
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