This product is a Ramos (RA 1) B cell engineering tool based on the Solid lipid nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (AAVS1-huIgH296-SpCas9-RS-1 ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | CD2 |
| Insert Clone | 7H196 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | huIgH296 |
| Nuclease | SpCas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | Regorafenib |
| Particle Size | <1000 |
| Charge (mv) | <-1 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Prostate cancer; Lung cancer; Ovarian cancer |
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