This product is a GA-10 (Clone 4) B cell engineering tool based on the Magnetic nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (hROSA26-tracr RNA-Cas9-(Z)-4-Hydroxytamoxifen ) genome editor.
| Host Cell | GA-10 (Clone 4) |
| Target | CD2 |
| Insert Clone | MRCOX-54 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 10-50 |
| Charge (mv) | 10 to 55 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | VSV |
| Vector Name | BCpCDH7 |
| Targeting Diseases | Breast cancer; Prostate cancer; Lung cancer; Ovarian cancer |
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