This product is a Raji-Luc2 B cell engineering tool based on the Dendrimers (Fucoidan/P-selectin) delivery system and CRISPR-based (hROSA26-huIgH296-Cpf1-RS-1 ) genome editor.
| Host Cell | Raji-Luc2 |
| Target | CD20 |
| Insert Clone | Leu-16 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | huIgH296 |
| Nuclease | Cpf1 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Large DNA sequences |
| Vehicles | Dendrimers |
| Ligand/Receptor | Fucoidan/P-selectin |
| Active Agents | Talazoparib, temozolomide |
| Particle Size | 10-1000 |
| Charge (mv) | −2 to -30 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Lung cancer; Breast cancer; Prostate cancer; Melanoma |
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