This product is a MC116 B cell engineering tool based on the Nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (CCR5-SpCas9-Cas9-Nocodazole ) genome editor.
| Host Cell | MC116 |
| Target | CD24 |
| Insert Clone | PP6373 |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | SpCas9 |
| Nuclease | Cas9 |
| Enhancer | Nocodazole |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | [Ru(bpy)2(tip)]2+, RBT |
| Particle Size | <500 |
| Charge (mv) | <-1 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Colorectal cancer; Breast cancer; Lung cancer; Esophageal squamous cell carcinoma; Bladder cancer |
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