This product is a P3HR-1 B cell engineering tool based on the Quantum dots (MUC1 aptamer/MUC1) delivery system and CRISPR-based (hROSA26-crispr RNA-SpCas9-RS-1 ) genome editor.
| Host Cell | P3HR-1 |
| Target | CD24 |
| Insert Clone | SWA11 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Quantum dots |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | <100 |
| Charge (mv) | −3 to -77 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | MSCV |
| Vector Name | BCpCDH6 |
| Targeting Diseases | Colorectal cancer; Breast cancer; Lung cancer; Esophageal squamous cell carcinoma; Bladder cancer |
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