This product is a SU-DHL-8 B cell engineering tool based on the Nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (SHS-321-crRNA:tracrRNA duplex-Cas12-Nocodazole ) genome editor.
| Host Cell | SU-DHL-8 |
| Target | CD26 |
| Insert Clone | D6D8K |
| Safe Harbor Sites (SHS) | SHS-321 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | Nocodazole |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Mouse genome E-1 |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 10-1000 |
| Charge (mv) | 10 to 35 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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