This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (Dexamethasone/Glucocorticoid receptor) delivery system and CRISPR-based (hROSA26-crRNA:tracrRNA duplex-Cas12-(Z)-4-Hydroxytamoxifen ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | CD276 |
| Insert Clone | BCWJC-1173 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Dexamethasone/Glucocorticoid receptor |
| Active Agents | ESC8 |
| Particle Size | 20-150 |
| Charge (mv) | −3 to -77 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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