This product is a GA-10 B cell engineering tool based on the Gold nanoparticles (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (SHS-323-crRNA:tracrRNA duplex-Cas12-Brefeldin A) genome editor.
| Host Cell | GA-10 |
| Target | CD276 |
| Insert Clone | BG-49E |
| Safe Harbor Sites (SHS) | SHS-323 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | Brefeldin A |
| Targeting Strategy | pH-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 20-3000 |
| Charge (mv) | ≤50 |
| Total Atom Count | -57,000,000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | MSCV |
| Vector Name | BCpCDH6 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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