This product is a BC-1 B cell engineering tool based on the Nanoparticles (SS-Fc/Carcinoembryonic antigen) delivery system and CRISPR-based (hROSA26-crRNA:tracrRNA duplex-SpCas9-3'-Azido-3'-deoxythymidine ) genome editor.
| Host Cell | BC-1 |
| Target | CD276 |
| Insert Clone | MAb-B |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | SpCas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH responsive |
| Insertion sites | Mouse genome E-2 |
| Vehicles | Nanoparticles |
| Ligand/Receptor | SS-Fc/Carcinoembryonic antigen |
| Active Agents | [Ru(bpy)2(tip)]2+, RBT |
| Particle Size | <500 |
| Charge (mv) | <-25 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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