This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (Transferrin/Transferrin receptor) delivery system and CRISPR-based (SHS-255-SpCas9-NLS-Cas9-3'-Azido-3'-deoxythymidine ) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | CD3D |
| Insert Clone | FF539 |
| Safe Harbor Sites (SHS) | SHS-255 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Large DNA sequences |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Transferrin/Transferrin receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | ≤10000 |
| Charge (mv) | −18 to -84 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Liver cancer; Lung cancer; Colon cancer |
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