This product is a DG-75 [D.G.-75] B cell engineering tool based on the Gold nanoparticles (Dexamethasone/Glucocorticoid receptor) delivery system and CRISPR-based (hROSA26-huIgH296-Cas12-RS-1 ) genome editor.
| Host Cell | DG-75 [D.G.-75] |
| Target | CD47 |
| Insert Clone | 5F9 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | huIgH296 |
| Nuclease | Cas12 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Dexamethasone/Glucocorticoid receptor |
| Active Agents | ESC8 |
| Particle Size | 20-150 |
| Charge (mv) | −10 to -50 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Colon cancer |
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