This product is a HS-Sultan B cell engineering tool based on the Dendrimers (MUC1 aptamer/MUC1) delivery system and CRISPR-based (AAVS1-sgRNA-Cpf1-Nocodazole ) genome editor.
| Host Cell | HS-Sultan |
| Target | CD70 |
| Insert Clone | 27B3 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | Nocodazole |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Dendrimers |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 10-500 |
| Charge (mv) | −18 to -84 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | Baculovirus-AAV |
| Vector Name | BCpCDH4 |
| Targeting Diseases | Liver cancer; Lung cancer; Colon cancer |
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