This product is a DS-1 B cell engineering tool based on the Solid lipid nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (SHS-323-SpCas9-Cas9-L755507 ) genome editor.
| Host Cell | DS-1 |
| Target | CD70 |
| Insert Clone | FF95-36F_FF |
| Safe Harbor Sites (SHS) | SHS-323 |
| gRNA | SpCas9 |
| Nuclease | Cas9 |
| Enhancer | L755507 |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Human genome |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | [Ru(bpy)2(tip)]2+, RBT |
| Particle Size | 20-150 |
| Charge (mv) | <-1 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | Baculovirus-AAV |
| Vector Name | BCpCDH4 |
| Targeting Diseases | Liver cancer; Lung cancer; Colon cancer |
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