This product is a Ramos.2G6.4C10 B cell engineering tool based on the Gold nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (hROSA26-sgRNA-Cpf1-(Z)-4-Hydroxytamoxifen ) genome editor.
| Host Cell | Ramos.2G6.4C10 |
| Target | CD70 |
| Insert Clone | MFX-3353 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | Thymoquinone |
| Particle Size | 1-100 |
| Charge (mv) | −25 to -125 |
| Total Atom Count | ~20,000,000 |
| Surface Atoms (%) | ~4 |
| Specific Surface Area (m2/g) | ~8 |
| Vector Type | RABV |
| Vector Name | BCpCDH8 |
| Targeting Diseases | Liver cancer; Lung cancer; Colon cancer |
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